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Item#: 9SIA0KZ0950808

SAM-e 400 mg (Double Strength) - 30 Tablets by Doctor's Best

  • Doctor's Best

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Suitable for vegetarians

Science-based nutrition

Dietary supplement

Enhances mood and neural function

Promotes joint comfort and mobility

Supports liver health and detoxification

Our SAMe 200 contains 200 mg of active SAMe in each tablet. Doctor's Best utilizes only the highest quality Italian SAMe available on the market. This ensures that you receive the most potent SAMe product with the highest percentage of the active S‚S form per serving‚ bar none.

S-Adenosyl Methionine (SAMe) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. SAMe is involved in numerous biochemical reactions in tissue including the liver‚ joints and brain. SAMe is also required for the biosynthesis of critical neurotransmitters and hormones.

Supplementing with SAMe

The manufacturing process of SAMe yields two forms‚ the S‚S and the R‚S isomers. The S‚S isomer is the active form that mediates biochemical activity in the human body‚ whereas the R‚S form is considered to be biologically inactive. The Italian SAMe used in our SAMe 200 is processed to yield the highest available percentage of the active pure S‚S form on the market.

SAMe and Joint Function

SAMe may enhance cartilage protection and promote the synthesis of proteoglycans‚ essential components of connective tissue. Clinical studies show an ability of SAMe to enhance mobility and movement‚ and promote joint comfort.

SAMe and Neural Health

SAMe-catalyzed methylation reactions promote the synthesis of neurotransmitters‚ which have the potential to promote enhanced mood. SAMe may also upregulate the production of phosphatidylcholine‚ supporting cognitive function.

SAMe and Liver Function

SAMe enhances liver synthesis of glutathione‚ an antioxidant. Glutathione promotes detoxification and liver protection. Studies show SAMe may protect liver tissue from injury caused by a number of toxins.

These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose? treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.


Doctor's Best






Active Ingredients
Serving Size: 1 TabletServing per container: 30 servingsAmount Per Serving %DVS-Adenosyl Methionine 400 mg †(from 800 mg of SAM-e tosylate disulfate)----------------------------------------------------------------------------------------------------Other Ingredients: Cellulose gel‚ methacrylic acid copolymer‚ compritol 888ATO‚ talc‚ triethyl citrate‚ titanium dioxide‚ magnesium stearate‚ mannitol‚ glycerol palmitostearate‚ silica‚ medium chain triglycerides‚ sodium starch glycolate‚ and iron oxide.The SAMe found in Doctor's Best SAMe 400mg is free from yeast‚ dairy‚ gluten‚ soy‚ wheat‚ and artificial flavoring.
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