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Pros: Since several PC Nvidia graphics cards "just work" now in OSX since 10.8 / 10.9, this card makes a very cost effective upgrade for older Mac Pro workstations with aging video cards.
Specifically, I used this card in a 2008 Dual Quadcore Mac Pro.
One of the benefits, aside from a low cost to high performance ratio is that it only requires a single power cable, opposed to the 2 required for some of the higher up GPUs. The special power chords required to use these in a Mac Pro can be obtained elsewhere.
No drivers need to be downloaded to make this work in the latest versions of OSX, but you will need to download the CUDA drivers from the Nvidia website to take advantage of that feature.
Using Luxmark 2.1 as an OpenCL benchmarking tool, I saw a significant improvement in GPU score.
It is also just as quiet as the card it replaced.
Cons: (Cons mentioned here are only in relation to using it in a Mac Pro.)
A minor item of note, but you will not see the Mac bootup screen on this card. Display through this card on a Mac Pro kicks in at the login screen. I kept the original video card in the system with a secondary monitor attached, to see that process there. But even if I hadn't, I wouldn't really be bothered.
Also, some adobe configuration files will need to be edited to have the GPU utilized by such applications as Adobe Premiere and Adobe After Effects. This is not terribly difficult and the steps can be easily found online.
Other Thoughts: I was initially tempted to upgrade with a 660 or 670 series GPU, but the 650 won be over by being the "best bang for the buck" and with the fact that it didn't require two power cables. I can now keep the possibility open to add a 2nd video card of necessary, and have the 2nd onboard power port available to do so.
So far, I am very pleased with this upgrade and have not run into any real incompatibility issues using it in OSX.