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Pros: Easy to set up. Booting from USB is great. Ran at first power up.
Cons: I built this to be a workstation for CFD calculations. I used 2 Opteron 2.6 GHz 12 core processors for a total 24 cores. Had to make several BIOS and operating system tweaks to finally get the system to run my test case about 10% slower than my Intel I7 2.3 quad core notebook. Unacceptably slow. Opterons don't seem to be good for intensive calculation work.
Other Thoughts: Will not make a good boat anchor either. I swapped to an Intel board running 2 xeon 2.0 Ghz 8 core processors for a total of 16 cores. I am now able to double the iterations in my test project and calculate in about 1/3 the time it took on my notebook.