Improve your productivity with a top-rated ergonomic computer mouse. Top models have a sensitive optical engine that works over different surfaces. They come with a button that gives you adjustable control over the dots-per-linear-inch (DPI) level for improved responsiveness. A wired ergonomic optical mouse comes with a plug-in cable, so you don't have to worry about batteries. In contrast, a wireless mouse has a receiver that plugs into any compatible USB port for a tidier, cord-free workspace. Consider an ergonomic vertical mouse with a unique design that helps keep the wrist in a neutral position, reducing the risk of strain.

Wireless Computer Ergonomic Mice Deliver Accuracy On Rough Surfaces

A wireless computer ergonomic mouse combines a handshake grip with control buttons and multiple DPI levels to improve tracking. The ergonomic thumb-rest and a grip that fits the contour of your palm offer maximum comfort. Consider an ergonomic wireless mouse that boasts a textured rubber surface to assure a solid, natural grip. Premium models may come with up to five buttons to expand your control. Hybrid options offer a dual-mode connection that allows you to shift between Bluetooth® or Radio Frequency (RF) mode to adapt to different wireless working conditions. Choosing a mouse that runs with a sensitive optical engine will help ensure that it works with a variety of mousepad accessories.

Wired Optical Mice Provide Secure, Faster Connections

A top rated wired ergonomic optical mouse comes with a thumb groove and rubber covers for comfort, making it a suitable pick for extended gaming sessions. Some wired models may offer an energy-saving function to help cut down on your cost. Other models may have indicating lights that circle your thumb, making it easier to spot in low-lit conditions while delivering an elegant look. Gaming mice that come with a removable wrist rest provide added protection from discomfort. To reduce hand fatigue, be sure to choose an ergonomic optical mouse with a connection cable that's long enough to reach your computer. Most wired mice come equipped with a USB interface and plug-and-play support, making them easy to install and use in minutes.

Vertical Gaming Mice Have Customizable Buttons

An ergonomic vertical mouse offers a natural handshake position to reduce muscle strain. It also provides advanced optical tracking and a dedicated cursor speed switch, resulting in less hand movement. Some models allow you to easily control your cursor speed via a switch button. Vertical gaming mice may also include a unifying receiver that enables you to pair up to three compatible input devices for convenience. Choose a model that offers silent buttons to maintain quiet working conditions. Some ergonomic wireless mice have a concave area for the thumb and a little extended bottom edge for the pinky finger, enabling smoother movement and a comfortable grip. Look for models that come with dedicated software, which provides additional options such as customizing control buttons to fit specific tasks.

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Anker 2.4G Wireless Vertical Ergonomic Optical Mouse, 800 / 1200 /1600 DPI, 5 Buttons for Laptop, Desktop, PC, Macbook - Black
Anker 2.4G Wireless Vertical Ergonomic Optical Mouse, 800 / 1200 /1600 DPI, 5 Buttons for Laptop, Desktop, PC, Macbook - Black

+ $7 off w/ promo code MKTE45, limited offer

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  • $29.99 –
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"Solid mouse. Easy to use the buttons and the arm/wrist position is much better."

  • 2
Evoluent Vertical Mouse D Right Wireless Medium
Evoluent Vertical Mouse D Right Wireless Medium
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  • $117.72 –

"Soft materials that dont leave a sort of rug burn."

"-The M575 and its predecessors have been my gp-to for years, hands down the best mouse on the market for the money. Accurate and lightweight, they'll last a number of years if given decent care (I recommend one of the custom-fit zipper cases). - They shipped it so doggone fast that it arrived two days early! Now THAT is impressive!"

  • 5
Eureka Ergonomic® 60" Z-Shaped Large Gaming Desk with LED Lights, Home Office Desk with Free Mouse pad Carbon Fiber Texture Desktop, Gift for Gamer, Black
Eureka Ergonomic® 60" Z-Shaped Large Gaming Desk with LED Lights, Home Office Desk with Free Mouse pad Carbon Fiber Texture Desktop, Gift for Gamer, Black
  • Type: Z Shaped
  • Surface Color: Black
  • Surface Material: Carbon Fiber Texture
  • Surface Load Capacity: 500 lbs.
  • Model #: ERK-Z60-B
  • Item #: 9SIAEVHGW94396
  • Return Policy: View Return Policy
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  • $279.99 –
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"Large, plenty of space for 2 monitors, my computer tower and my ps4."

  • 6
Rii K12 UltraSlim Wireless Keyboard Mouse Touchpad Metal Tablet/Phone (BLACK)
Rii K12 UltraSlim Wireless Keyboard Mouse Touchpad Metal Tablet/Phone (BLACK)
  • Design Style: Slim
  • Keyboard Color: Black
  • Model #: mini K12
  • Item #: 9SIAGFHK343691
  • Return Policy: View Return Policy
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  • $37.50 –

"-Keys and touch pad work fine as expected. -No noticeable lag when used with a pi, nvidia shield or nexus player. -Cheap compared to other smaller"

"Height Adjustable Very quick and easy to assemble Sturdy"

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MSI Forge GK310 Mechanical Gaming Keyboard & Mouse Combo w/ Magnetic Cover - Hot Swappable Mechanical Red Switches, RGB, Ergonomic, Anti-GHOSTING, Angle-Adjustable
MSI Forge GK310 Mechanical Gaming Keyboard & Mouse Combo w/ Magnetic Cover - Hot Swappable Mechanical Red Switches, RGB, Ergonomic, Anti-GHOSTING, Angle-Adjustable
  • Brand: MSI
  • Keyboard Interface: USB 2.0
  • Design Style: Gaming
  • Layout: Full-size
  • Model #: FORGE GK310 COMBO RED US
  • Item #: 9SIA24GKD18027
  • Return Policy: View Return Policy
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  • $51.04 –
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"Loving it. Very nice keyboard."

  • 9
Razer Basilisk V3 Pro Customizable Wireless Gaming Mouse with Razer HyperScroll Tilt Wheel
Razer Basilisk V3 Pro Customizable Wireless Gaming Mouse with Razer HyperScroll Tilt Wheel
  • Part Number: RZ01-04620100-R3U1
  • Resolution (DPI): 30000 dpi
  • Hand Orientation: Right Hand
  • Model #: RZ01-04620100-R3U1
  • Item #: N82E16826153335
  • Return Policy: 30-Day Return Policy
  • $159.99
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  • $129.99 –
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"Really fast service from Newegg, product came really good conditions, mouse really perfect and fast. Thank you!"

  • 10
ASUS Gaming Desktop PC GM700TZ-NS776 AMD Ryzen 7 9800X3D 32GB DDR5 1TB NVMe SSD AMD Radeon RX 9070 XT Windows 11 Home
ASUS Gaming Desktop PC GM700TZ-NS776 AMD Ryzen 7 9800X3D 32GB DDR5 1TB NVMe SSD AMD Radeon RX 9070 XT Windows 11 Home
  • GPU/VGA Type: AMD Radeon RX 9070 XT
  • CPU Name: AMD Ryzen 7 9800X3D
  • Memory Capacity: 32GB DDR5
  • SSD: 1TB NVMe
  • Model #: GM700TZ-NS776
  • Item #: N82E16883221811
  • Return Policy: 15-Day Return Policy
  • $2,099.99
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  • $1,899.99 –
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"it's beautiful good price to performance"

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Mount-It! Under Desk Keyboard Tray with Ergonomic Wrist Rest Pad |17.25 Inch Track
Mount-It! Under Desk Keyboard Tray with Ergonomic Wrist Rest Pad |17.25 Inch Track
  • Type: Desk Accessories & Organizers
  • Model #: MI-7137
  • Item #: 9SIA3C98NE5013
  • Return Policy: View Return Policy
  • $96.99
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  • $77.99 –
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Corn Electronics Keyboard Wrist Rest Pad Ergonomic Laptop Computer Keyboard Wrist Rest Pad Support Cushion for PC Gaming(14.5 inch x 3.2 inch)
Corn Electronics Keyboard Wrist Rest Pad Ergonomic Laptop Computer Keyboard Wrist Rest Pad Support Cushion for PC Gaming(14.5 inch x 3.2 inch)
  • Color: Black
  • Size: N/A
  • Model #: DZ-PAD-002
  • Item #: 9SIA4RE6FR3810
  • Return Policy: View Return Policy
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  • $20.35 –
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"It does its job, is nice and soft"