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Pros: This is the best ergonomic mouse I've used. I had issues with my wrist getting sore after working too long (CAD) with a regular mouse, but this got rid of them. After getting used to it, this is now my favorite mouse when just browsing the web and wasting time.
Cons: Not for gaming. I'll use it for slower games like the Elder Scrolls games, but it doesn't have the fast precision that is needed for twitch shooters like UT or Quake. I find it easier to have fine control with sideways motion than The button locations are different than a standard mouse, so it took a while (week) to really get used to the controls.