Will this drive work in an external hard drive enclosure as a drive for daily backups?

If it's the right size bay. You'll get faster back ups if you have an open internal SATA.

Can these drives be used as a Windows 10/64 desktop computer internal storage?

Sure, the 'NAS' designation is to classify it's more robust usage than a desktop as a NAS drive as part of a RAID is expected to take heavy read/writes in a 24/7 setting. You can always drive a Bugatti to the grocery store.

Anyone using these in a TiVo? If so, any issues?

I don't use TiVo, but you shouldn't run into issue w/ that drive unless you got one that was DoA for some reason. I have four of these in a RAID5 for my Plex movies & I haven't had better performance for the dollar. If you plan on using these for RAID & need lots of throughput I suggest the SAS enterprise drives, if they & the controller needed for them are within your budget.

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Seagate IronWolf 4TB NAS Hard Drive 5900 RPM 64MB Cache SATA 6.0Gb/s CMR 3.5" Internal HDD for RAID Network Attached Storage ST4000VN008

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Seagate IronWolf ST4000VN006 4TB 5400 RPM 256MB Cache SATA 6.0Gb/s 3.5" Internal Hard Drive

$99^.99–

Range of capacities up to 14TB.
Workload rate of 180TB/year.
Optimized for NAS with AgileArray, enables dual-plane balancing and RAID optimization in multi-bay environments.
Actively protect your NAS with IronWolf Health Management.
Rotational Vibration (RV) sensors.
Always-on, always-accessible 24x7 performance.
1M hours MTBF.

🔥Don't forget your OS, we have Windows 11 OEM, Download and USB versions available

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Seagate IronWolf 4TB 3.5 SATA HDD 64MB

Model
Brand	Seagate
Series	IronWolf
Model	ST4000VN008
Packaging	Bare Drive

Performance
Interface	SATA 6.0Gb/s
Capacity	4TB
Recording Technology	CMR
RPM	5900 RPM
Cache	64MB

Features
Features	Optimized for NAS with AgileArray. AgileArray enables dual-plane balancing and RAID optimization in multi-bay environments, with the most advanced power management possible. Actively protect your NAS with IronWolf Health Management focusing on prevention, intervention, and recovery. High performance means no lag time or downtime for users during workload traffic for the NAS. Seagate leads the competition with the highest-performing NAS drive portfolio. Rotational Vibration (RV) sensors. First in its class of drives to include RV sensors to maintain high performance in multi-drive NAS enclosures. Range of capacities up to 16TB. More capacity options means more choices that will fit within the budget. Seagate provides a scalable solution for any NAS use-case scenario. Do more in multi-user environments. IronWolf provides a workload rate of 180TB/year. Multiple users can confidently upload and download data to the NAS server, knowing IronWolf can handle the workload, whether you are a creative professional or a small business. Designed for always-on, always-accessible 24x7 performance. Access data on your NAS any time, remotely or on site. 1M hours MTBF represents an improved total cost of ownership (TCO) over desktop drives with reduced maintenance costs.
Usage	For NAS systems

Dimensions
Form Factor	3.5"
Height (maximum)	26.11mm
Width (maximum)	101.85mm
Length (maximum)	146.99mm

Additional Information
First Listed on Newegg	October 20, 2016

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Seagate IronWolf 4TB NAS Hard Drive 5900 RPM 64MB Cache SATA 6.0Gb/s CMR 3.5" Internal HDD for RAID Network Attached Storage ST4000VN008

Learn more about the Seagate ST4000VN008

Customer Reviews of the Seagate ST4000VN008

Warranty & Returns

Warranty, Returns, And Additional Information

Warranty

Return Policies

Manufacturer Contact Info

Item#: N82E16822179005

Seagate IronWolf 4TB NAS Hard Drive 5900 RPM 64MB Cache SATA 6.0Gb/s CMR 3.5" Internal HDD for RAID Network Attached Storage ST4000VN008

Learn more about the Seagate ST4000VN008

Customer Reviews of the Seagate ST4000VN008

Warranty & Returns

Warranty, Returns, And Additional Information

Warranty

Return Policies

Manufacturer Contact Info