will this ram work on Mac G5 Quad Core 2.5?

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By looking at the default specs for the system, yes you can put this ram in the Mac, it uses the same speed ram as what this is. In fact the system can hold up to 16 GB of ram. However you would need bigger memory modules. Note: From my experience with Macs they tend to be picky when you don't have the ram paired with another of the same size.  I can't garentee that for your system its just a precaution.

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