With the all the connectors in the back, are there any case compatibility issues to be aware of?

The product features a Back-Connect Design, which moves the connectors to the back to provide a cleaner and neater setup.

What form factor is this motherboard?

The form factor of this motherboard is 243.84mmx304.8mm.

The motherboard size is 243.84mm x 304.8mm.

Yes, the motherboard features a back-connect design that moves connectors to the back, providing a cleaner and neater appearance.

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MSI PRO Z890-S WIFI PZ LGA 1851 Intel Z890 243.84mmx304.8mm (280) Motherboards - Intel

Latest DDR5 Memory: A huge step of DDR performance enhancement with the latest DDR5 memory and MSI Memory Boost technology.
Wi-Fi 7: The latest wireless solution with a new 320MHz channel, achieving a maximum transmission speed of 5.8Gbps, which is 2.4 times faster than Wi-Fi 6/6E.
2.5G Network Solution: Featuring premium 2.5G LAN to deliver better network
experience.
ThunderboltTM 4 port: ThunderboltTM 4 brings Thunderbolt to USB-C at true 40 Gb/s speeds, 8K display support, Daisy-Chain, Multi-Port Accessory
Architecture and USB 4.0 compliant.
Lightning USB 20G: Built-in USB 3.2 Gen 2x2 port, offers 20Gbps transmission speed, 4X faster than USB 3.2 Gen 1.
Frozr AI Cooling Detect CPU & GPU temperatures and automatically adjust system fan duty to a proper value.
M.2 Shield FROZR: Strengthened built-in M.2 thermal solution. Keeps M.2 SSDs safe while preventing throttling, making them run faster.
Back-Connect Design:Move the connectors to the back to provide a cleaner and neater