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X99 Dual CPU Motherboard Combo Xeon with E5 2683 V4 DDR4 64GB RECC Up To 256GB Support M.2 NVMe VGA USB3.0 10* SATA3.0
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TPN-Q244 14-DV Main Board M16647-001 Version Number: DA0G7GMB8G0
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TPN-Q244 14-DV Main Board M16647-001 Version Number: DA0G7GMB8G0

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Z8NR-D12-SYS 1366 pin dual channel server main board
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Z8NR-D12-SYS 1366 pin dual channel server main board

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Wanquan R520G7 Server Main Board 11011989 S7007G2NR-LNV-WM
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Wanquan R520G7 Server Main Board 11011989 S7007G2NR-LNV-WM

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X10SLL + -F single server main board E3-1200 series V3
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X10SLL + -F single server main board E3-1200 series V3

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TPN-Q225 13-AW Main Board L71986-601 Version Number: DA0X3AMBAI0
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TPN-Q225 13-AW Main Board L71986-601 Version Number: DA0X3AMBAI0

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PCIe 3.0/4.0 Slimline SAS SFF-8654 Host Adapter Card with SFF-8654 to U.2 SFF-8639 NVMe SSD Cable Kit, Mainboard Enterprise Storage Expansion Set
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System X3200 Server Main Board 43W5050 43W5057 43W4982
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System X3200 Server Main Board 43W5050 43W5057 43W4982

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840 PE840 Server Main Board XM091 0RH822
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840 PE840 Server Main Board XM091 0RH822

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T420 Dual server main board N567W LGA1356 DDR3
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T420 Dual server main board N567W LGA1356 DDR3

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FOR LA-D451P for Flex 4-1470 510-14ISK main board
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FOR 5B20F86140 for Flex 2-15 Main Board 13308-1
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X3650M4/X3550M4 Server Main Board 00AM209 00Y8457 Support
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X3650M4/X3550M4 Server Main Board 00AM209 00Y8457 Support

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FOR 280 288 PRO G1 G2 MT Main Board 1150 1151 G1G2 FX-ISL-1
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FOR 280 288 PRO G1 G2 MT Main Board 1150 1151 G1G2 FX-ISL-1

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FOR 08274-2 48.4CR05.021 for 4810T Main Board
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FOR 741980-501 for 10-e Main Board DA0Y02MB6C1
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FOR 448.05303.0011 for ES1-531 Main Board 14285-1
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FOR 448.05303.0011 for ES1-531 Main Board 14285-1

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X9DA7 Dual Workstation Server Main Board LGA2011 C602
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X3500 M5 Dual Server Main Board 00MW076 00AL597 01KN185
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X3500 M5 Dual Server Main Board 00MW076 00AL597 01KN185

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FOR L19050-601 LA-G121P for 15-BS main board EPG52
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FOR CN-0R188P For 1440 I1440 main board
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FOR DA0ZABMB6E0 for E5-523G Main Board
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FOR DA0ZRVMB6D0 for E5-532G Main Board
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FOR LA-4602P for Y550 Main Board
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/ T330 T130 Server Main Board 0FGCC7 026G78 R31TT1
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/ T330 T130 Server Main Board 0FGCC7 026G78 R31TT1

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X306 Main Board X306 Server Main Board FRU: 13M8300 23K4446
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FOR Desk 705 G1 DM 755528-001 601 754910-001 003 Main Board
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FOR 4300 PRO MS-7782 Main Board 676358-001/675885-001
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R730 R730XD Server Main Board 599V5 WCJNT R53PY 4N3DF
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R730 R730XD Server Main Board 599V5 WCJNT R53PY 4N3DF

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FOR 6005 PRO Main Board 531966-001 503335-001
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FOR PRO 3340MT 3348MT H67 Main Board 694620-001 660515-001
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T320 T420 Server Main Board 7MYHN DJ7HC 7C9XP W7H8C NK701
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FOR DX2810 2818 G45 Main Board DDR2 508460-001 506521-001
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FOR 6280 6200 PRO Main Board 615114-001 614036-002 611794
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Server motherboards play a pivotal role in facilitating efficient communication between CPUs and other server hardware. While functionally similar to traditional computer motherboards, server motherboards are specifically designed to handle more intensive workloads, higher temperatures, and environmental stress typical in data centers and high-density IT network environments. Selecting the appropriate server motherboard significantly impacts server performance, reliability, and scalability.

Optimize Your Space with the Right Server Motherboard

Choosing the appropriate form factor is crucial when selecting a server motherboard. Popular server motherboard form factors include ATX, Mini-ITX, Micro-ATX, and specialized boards such as Mini-ITX motherboards with 10GbE or dual LAN support. An ATX motherboard offers compatibility with multiple redundant power supplies and expansive hardware support, making it ideal for high-capacity applications. In contrast, Mini-ITX and Micro-ATX motherboards, with their compact designs, are perfect for environments where space optimization is vital, such as NAS servers or densely packed data centers. Be sure to consider the rack type and required components when choosing the right form factor for your server chassis

Maximize Compute Power with Flexible CPU Compatibility

Server motherboard selection directly influences your choice of CPUs. Whether you're configuring a workstation motherboard or a dedicated server motherboard, compatibility with CPUs such as AMD EPYC, Intel Xeon W, Ampere Altra, or Threadripper Pro is essential. Motherboards designed specifically for EPYC CPUs, such as EPYC 4005 , EPYC 4004, EPYC 7003, EPYC 9004, and EPYC 9005, offer robust compute performance and flexibility. Options like dual processor motherboards, dual AMD EPYC motherboards, or quad processor motherboards further enhance compute capability and scalability.

Motherboards featuring sockets such as AMD SP5 or AM5 provide extensive options for CPU combinations. Selecting an AMD EPYC motherboard or Intel-compatible dual Xeon motherboard enables cost-effective upgrades and ensures performance consistency across server deployments.You should be able to keep your motherboard in most cases.

Enhanced Storage and Memory Support

Server motherboards also dictate your server memory and storage solutions. ECC memory, crucial for error correction and reliability in servers, requires a compatible motherboard. Many server motherboards support both ECC and non-ECC memory, providing flexibility based on your performance and budget needs. Compatibility with specialized storage solutions like SAS motherboards also enhances storage efficiency and data throughput, critical in demanding IT environments.

Effective Cooling and Energy Efficiency

Cooling is a primary consideration when deploying servers. Efficient cooling reduces operational costs and minimizes system downtime due to overheating. Smaller form factors like Micro ITX often require enhanced cooling features integrated directly into the motherboard design. Selecting a motherboard with robust built-in cooling capabilities can significantly reduce cooling-related expenditures. Manufacturers such as Supermicro deliver server motherboards that incorporate advanced cooling technologies even in compact form factors, contributing to environmental sustainability and compliance with global energy standards.

FAQs about Server Motherboards

  • How do I choose the right form factor for my server chassis?

    Match your motherboard’s form factor (ATX, Micro-ATX, Mini-ITX) to both your rack or tower chassis and intended use. ATX fits larger chassis with multiple power supplies and expansion slots; Micro-ATX and Mini-ITX work best in compact NAS or blade-style chassis where space and airflow are at a premium.
  • What cooling features should I look for in a server motherboard?

    Look for integrated heatsinks on VRMs, reinforced fan headers, and support for chassis-level airflow designs. Boards from vendors like Supermicro often include fan-control profiles and thermal sensors to optimize cooling in dense rack environments.
  • Can I use non-ECC memory on a server motherboard?

    Only if the board explicitly supports it. Many server boards let you choose between ECC and non-ECC DIMMs—but to benefit from error-correcting features in critical workloads, always pair ECC memory with an ECC-capable motherboard.

Bestselling Server Motherboards Reviews:

Anonymous
11/12/2025 7:31:12 AM
Great Epyc motherboard

“ I would recommend this MB for a small Epyc server build (nice ATX size). ”

Supermicro Server Motherboard MBD-H13SSL-NT, Socket SP5 AMD 4th Gen EPYC™ 9004/9005, Up to 3TB 3DS ECC RDIMM DDR5, ATX. Support of "EPYC 5th Gen 9005 Series"
Dgunnell
10/21/2025 7:12:25 AM
Nice server motherboard

“ I would recommend this motherboard for a home based or small business server ”

ASRock Rack Server Motherboard EC266D2I Mini-ITX 2x 1GLan Single Socket (LGA 1700) Intel Xeon E-2400 series
John M.
9/16/2025 12:11:52 PM
A Cheaper and Better End State Workstation Configuration

“ The reason is that the board is most definitely designed to be a server motherboard. ”

GIGABYTE MH53-G40 Server Motherboard - AMD Ryzen™ Threadripper™ PRO 9000/7000 WX - E-ATX UP
RICHARD B.
8/18/2025 5:25:53 AM
Doing GREAT so far (updated 1 wek in)

“ I would definitely recommend this board for your server build. ”

ASRock Rack Server Motherboard B650D4U3-2L2Q/BCM Micro-ATX AMD EPYC™ 4004/4005 and AMD Ryzen™ 9000/8000/7000 Series Dual SFP28 (25GbE)
Anonymous
7/16/2025 11:50:37 AM
Epyc 4005 worked after bios update

“ Plenty of pcie lanes for small businesses or home lab I would still recommend this board to start with, as you can always use the two other pcie lanes for expansions and leave the full 16x for a GPU or whatnot. ”

ASRock Rack B650D4U-2L2T/BCM Micro-ATX Server Motherboard Single Socket AMD EPYC™ 4005/4004 and AMD Ryzen™ 9000/8000/7000 Series Processors (LGA 1718) B650E PCIe 5.0 Dual 10G Lan
Ryland P.
6/13/2025 9:24:32 AM
SFF server board crammed with features

“ Tons of features peculiar to server boards but in a SFF ”

Supermicro MBD-X13SCL-IF-O Intel LGA-1700 Single Socket Mini-ITX Server Motherboard
Anonymous
4/15/2025 10:18:04 AM
Perfect for a server

“ Overall a great choice for a server platform using Ryzen AM5 CPUs rather than EPYC or Xeon while getting mostly the same management features. ”

ASRock Rack B650D4U-2L2T/BCM Micro-ATX Server Motherboard Single Socket AMD EPYC™ 4005/4004 and AMD Ryzen™ 9000/8000/7000 Series Processors (LGA 1718) B650E PCIe 5.0 Dual 10G Lan