Is this brand new in the original manufacture's seal box?

yes, it's just the new in original Manufacture's seal box.

What type of socket is required for this CPU?

The required socket for this CPU is Socket sWRX8.

The power consumption of this CPU is 280W.

Yes, this CPU supports Windows 11.

No, this CPU does not come with integrated graphics.

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AMD Ryzen Threadripper PRO 5975WX - Ryzen Threadripper PRO 5000 WX-Series 32-Core 3.6 GHz Socket sWRX8 Workstation Processor - 100-100000445WOF