Can you use both M2 slots and all 8 sata ports simultaneously?

No. M2_1 is always available, but you would have to choose between M2_2 and x4 SATA ports. You would still have x8 PCIE2 lanes available or oculink that you could use to add other stuff with the right adapter though.

is this board able to run the higher wattage cpus after the bios update in the 7003 series? like the 7763/7H12 thats 280 watts?

Page 21 of the support Manual PDF does mention 280watt CPU support: download asrock com/Manual/ROMED8-2TBCM.pdf

Questions & Answers: AsRock Rack ROMED8-2T/BCM Server Motherboard Single Socket SP3 (LGA 4094), supports AMD EPYC™ 7003 (with AMD 3D V-Cache™ Technology*)/7002 series processors

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AsRock Rack ROMED8-2T/BCM Server Motherboard Single Socket SP3 (LGA 4094), supports AMD EPYC™ 7003 (with AMD 3D V-Cache™ Technology*)/7002 series processors

ATX (12" x 9.6")
Single Socket SP3 (LGA 4094), supports AMD EPYC™ 7003 (with AMD 3D V-Cache™ Technology*)/7002 series processors
8 DIMM slots (1DPC), supports DDR4 RDIMM, LRDIMM, RDIMM/LRDIMM-3DS, NVDIMM-N
7 PCIe4.0 x16
2 OCuLink (PCIe4.0 x4)
Supports 2 M.2 (PCIe4.0 x4 or SATA 6Gb/s)
10 SATA 6Gb/s
2 RJ45 (10GbE) by Broadcom BCM57416
Remote Management (IPMI)

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