Yes... run mine in Asus x299 Apex MB, it’s clocks and core speeds are much like my 9900k.

will these Core i9 processors run well on Windows 10?

The Intel Core i9-10920X processor supports Windows 11, which implies it should also run well on Windows 10.

Questions & Answers: Intel Core i9-10920X - Core i9 10th Gen Cascade Lake 12-Core 3.5 GHz LGA 2066 165W Desktop Processor - BX8069510920X

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Intel Core i9-10920X - Core i9 10th Gen Cascade Lake 12-Core 3.5 GHz LGA 2066 165W Desktop Processor - BX8069510920X

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